KATP Channel Subunits in Rat Dorsal Root Ganglia: Alterations by Painful Axotomy
نویسندگان
چکیده
منابع مشابه
KATP channel subunits in rat dorsal root ganglia: alterations by painful axotomy
BACKGROUND ATP-sensitive potassium (KATP) channels in neurons mediate neuroprotection, they regulate membrane excitability, and they control neurotransmitter release. Because loss of DRG neuronal KATP currents is involved in the pathophysiology of pain after peripheral nerve injury, we characterized the distribution of the KATP channel subunits in rat DRG, and determined their alterations by pa...
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Section of rat sciatic nerve (axotomy) increases the excitability of neurons in the L(4)-L(5) dorsal root ganglia (DRG). These changes are more pronounced in animals that exhibit a self-mutilatory behavior known as autotomy. We used whole cell recording to examine changes in the tetrodotoxin-sensitive (TTX-S) and the tetrodotoxin-resistant (TTX-R) components of sodium channel currents (I(Na)) t...
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Abdulla, Fuad A. and Peter A. Smith. Axotomyand autotomyinduced changes in Ca and K channel currents of rat dorsal root ganglion neurons. J Neurophysiol 85: 644–658, 2001. Sciatic nerve section (axotomy) increases the excitability of rat dorsal root ganglion (DRG) neurons. The changes in Ca currents, K currents, Casensitive K current, and hyperpolarization-activated cation current (IH) that may...
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ژورنال
عنوان ژورنال: Molecular Pain
سال: 2010
ISSN: 1744-8069,1744-8069
DOI: 10.1186/1744-8069-6-6